| No. | Hedge Fund | Shares | Value | Activity | % Port |
|---|---|---|---|---|---|
| 1. | EcoR1 Capital Oleg Nodelman | 1,706,469 | $224,912,614 | 10.79% | |
| 2. | Renaissance Technologies Jim Simons | 924,874 | $121,898,393 | +3% | 0.16% |
| 3. | Citadel Investment Group Ken Griffin | 883,945 | $116,503,951 | +43% | 0.02% |
| 4. | GMT Capital Thomas E. Claugus | 792,800 | $104,491,040 | +4% | 4.74% |
| 5. | AQR Capital Management Cliff Asness | 698,941 | $90,963,696 | -13% | 0.06% |
| Insider | Price | Amount | Total Value | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $103.00 | 1,621 | $166,961.54 | 101,621 | 2025-05-12 | Filing | |
| $99.71 | 100 | $9,971.00 | 100,000 | 2025-05-09 | Filing | |
| $98.91 | 19,216 | $1,900,677.62 | 99,900 | 2025-05-09 | Filing | |
| $98.10 | 80,684 | $7,915,471.55 | 80,684 | 2025-05-09 | Filing | |
| $119.65 | 12,000 | $1,435,800.00 | 27,932 | 2024-03-01 | Filing |
| Insider | Price | Amount | Total Value | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $177.78 | 3,415 | $607,126.55 | 20,449 | 2025-11-20 | Filing | |
| $182.60 | 717 | $130,924.85 | 390,826 | 2025-11-18 | Filing | |
| $181.81 | 5,517 | $1,003,071.15 | 391,543 | 2025-11-18 | Filing | |
| $180.88 | 8,382 | $1,516,131.13 | 397,060 | 2025-11-18 | Filing | |
| $180.09 | 3,384 | $609,410.69 | 405,442 | 2025-11-18 | Filing |
| No. | Name | Shares | Value | % Port |
|---|---|---|---|---|
| 1. | 5,906,945 | $778,535,352 | 0.01% | |
| 2. | 5,559,312 | $732,717,323 | 0.01% | |
| 3. | 2,836,652 | $373,855,443 | 0.08% | |
| 4. | 2,554,867 | $336,731,471 | 0.05% | |
| 5. | 1,867,886 | $246,187,375 | 0.01% |
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